Spinal cord patterning

Across TCGA patient cohorts, RNA activity of the Spinal cord patterning pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN11, SMTN, and TGFB3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord patterning activity versus SEPTIN11 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEPTIN11 →	+0.333	+0.045	<.001	<.001	3	7
OV	SMTN →	+0.715	+0.064	.006	.004	3	7
HNSC	TGFB3 →	+0.556	+0.092	<.001	<.001	3	7
CCRCC	THBS3 →	+0.824	+0.057	<.001	<.001	3	7
OV	THY1 →	+0.687	+0.066	<.001	<.001	3	7
BRCA	TIMP2 →	+0.654	+0.053	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021511 vs SEPTIN11 — BRCA

Explore this scatter interactively →