Spinal cord patterning

Across TCGA pan-cancer cohorts, RNA activity of the Spinal cord patterning pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BLCA and KICH, show the opposite pattern, with lower activity in tumor tissue.

BLCA, KICH, and KIRC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	Male	IV	−0.087	.001	8	view →
KICH	All	All	−0.062	<.001	7	view →
KIRC	All	II,III,IV	−0.023	<.001	7	view →
BRCA	All	II,III,IV	−0.053	<.001	6	view →
CHOL	All	All	−0.053	.003	4	view →
PAAD	All	All	+0.042	.005	4	view →
UCEC	All	All	−0.045	.005	2	view →
LUSC	Male	All	−0.029	.003	2	view →
LUAD	Female	All	−0.026	.013	2	view →
COAD	All	II,III,IV	−0.018	.047	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0021511–BLCA

Open the BLCA breakdown →