Spinal cord patterning

Across TCGA patient cohorts, RNA activity of the Spinal cord patterning pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF484, CBX7, and ZFP28, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord patterning activity versus ZNF484 in LUAD (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZNF484 →	+0.325	+0.121	.007	.003	3	4
BRCA	CBX7 →	+0.524	+0.274	<.001	<.001	3	3
BRCA	ZFP28 →	+0.515	+0.347	.001	.001	3	3
COAD	TRBV5-3 →	+0.169	+0.344	<.001	<.001	3	3
PDAC	SEMA5A →	+0.493	+0.151	.008	.004	3	3
BRCA	CDK20 →	+0.466	+0.308	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021511 vs ZNF484 — LUAD

Explore this scatter interactively →