Spinal cord patterning

Across TCGA patient cohorts, RNA activity of the Spinal cord patterning pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFT122, SUFU, and EXOC1_S470, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord patterning activity versus IFT122 in COAD (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IFT122 →	+0.762	+0.262	<.001	<.001	3	4
BRCA	SUFU →	+0.327	+0.392	<.001	<.001	3	3
OV	EXOC1_S470 →	-0.934	-0.286	<.001	<.001	3	3
GBM	GLI3_S980 →	+0.908	+0.418	<.001	<.001	3	3
LUAD	MTERF3 →	-0.356	-0.181	<.001	<.001	3	3
UCEC	ZBTB38_S130 →	-0.489	-0.248	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021511 vs IFT122 — COAD

Explore this scatter interactively →