Spinal cord patterning

Across TCGA cell cohorts, RNA activity of the Spinal cord patterning pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOGA3, CTSZ, and LYPLA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOGA3 grouped by Spinal cord patterning-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SOGA3 →	+0.250	+1.624	.006	<.001	3	4
BREAST	CTSZ →	-0.114	-0.827	.002	<.001	3	4
STOMACH	LYPLA1 →	-0.222	-1.266	<.001	.002	3	3
LARGE_INTESTINE	AK4 →	+0.220	+1.064	<.001	.001	3	3
STOMACH	CYB561D1 →	-0.201	-1.426	.009	<.001	3	3
STOMACH	PBX2 →	+0.143	+1.138	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOGA3 by Spinal cord patterning activity — BLOOD_Myeloma

Explore this box plot interactively →