Lipid storage

Across TCGA cell cohorts, RNA activity of the Lipid storage pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF39, HLA-A, and COQ10B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF39 grouped by Lipid storage-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ARHGEF39 →	+1.183	+1.257	<.001	.002	3	4
LIVER	HLA-A →	-1.413	-1.262	.002	<.001	3	4
SKIN	COQ10B →	+0.510	+1.371	<.001	<.001	3	4
SKIN	C10orf95 →	-0.224	-1.214	.001	<.001	3	4
BLOOD_Myeloma	TST →	+1.114	+1.391	.004	<.001	3	4
PANCREAS	TMEM25 →	-1.200	-1.029	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF39 by Lipid storage activity — LIVER

Explore this box plot interactively →