Antigen processing and presentation of exogenous peptide antigen via MHC class II

Across TCGA cell cohorts, RNA activity of the Antigen processing and presentation of exogenous peptide antigen via MHC class II pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB8, B2M, and TPRA1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of exogenous peptide antigen via MHC class II activity versus PSMB8 in OVARY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PSMB8 →	+2.176	+0.306	.001	<.001	3	8
BLOOD_Lymphoma	B2M →	+1.482	+0.547	.002	<.001	2	8
CNS	TPRA1 →	+0.660	+0.250	<.001	.001	3	6
LARGE_INTESTINE	HLA-B →	+3.871	+0.258	<.001	<.001	3	6
BLOOD_Myeloma	HLA-DRB5 →	+4.751	+0.565	.001	.004	3	5
OVARY	HLA-A →	+2.516	+0.333	<.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019886 vs PSMB8 — OVARY

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