Taurine metabolic process

Across TCGA patient cohorts, RNA activity of the Taurine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSAD, UBAP1L, and ACCS, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Taurine metabolic process activity versus CSAD in LIHC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	CSAD →	+1.017	+0.059	<.001	<.001	3	26
GBM	UBAP1L →	+0.665	+0.069	<.001	<.001	3	22
GBM	ACCS →	+0.932	+0.081	<.001	<.001	3	21
SCLC	DNAH1 →	+0.732	+0.114	.007	.009	1	23
GBM	TTLL3 →	+1.018	+0.091	<.001	<.001	3	21
GBM	SEC31B →	+0.690	+0.066	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019530 vs CSAD — LIHC

Explore this scatter interactively →