Taurine metabolic process

Across TCGA patient cohorts, RNA activity of the Taurine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNAJA1, TLN2, and FEN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Taurine metabolic process activity versus DNAJA1 in OV (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DNAJA1 →	-0.226	-0.046	.009	.002	3	7
BRCA	TLN2 →	+0.766	+0.087	<.001	<.001	3	7
PDAC	FEN1 →	-0.340	-0.080	<.001	<.001	3	7
OV	SORBS3 →	+0.443	+0.054	.002	.008	3	6
BRCA	COPZ2 →	+0.710	+0.079	<.001	<.001	3	6
BRCA	DCN →	+0.898	+0.076	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019530 vs DNAJA1 — OV

Explore this scatter interactively →