Taurine metabolic process

Across TCGA patient cohorts, RNA activity of the Taurine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THEMIS2, NEK3, and SRRD, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Taurine metabolic process activity versus THEMIS2 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THEMIS2 →	+0.563	+0.309	.007	.002	3	3
BRCA	NEK3 →	+0.417	+0.299	.004	.002	3	3
LSCC	SRRD →	-0.571	-0.562	<.001	<.001	3	3
LSCC	TFIP11 →	-0.491	-0.417	<.001	<.001	3	3
LSCC	MTHFSD →	-0.290	-0.374	<.001	.001	3	3
LSCC	PRSS16 →	-0.435	-0.335	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019530 vs THEMIS2 — BRCA

Explore this scatter interactively →