Taurine metabolic process

Across TCGA cell cohorts, RNA activity of the Taurine metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHGDH, FMO1, and CSAD, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHGDH grouped by Taurine metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PHGDH →	-0.399	-1.177	<.001	.003	3	8
LUNG_SCLC	FMO1 →	-0.355	-1.869	<.001	<.001	3	8
LUNG_SCLC	CSAD →	-0.269	-1.552	<.001	<.001	3	8
OVARY	CPXM1 →	-0.436	-1.451	<.001	<.001	3	7
BLOOD_Leukemia	ALG2 →	-0.254	-1.288	.001	.007	2	7
CNS	MORC3 →	-0.463	-1.262	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHGDH by Taurine metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →