Taurine metabolic process

Across TCGA cell cohorts, RNA activity of the Taurine metabolic process pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Mirin, PRIMA-1MET, and Bromosporine, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Mirin grouped by Taurine metabolic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Mirin →	-0.585	-0.407	.004	.023	3	2
BLOOD_Lymphoma	PRIMA-1MET →	-1.109	-0.949	.011	.016	3	2
BLOOD_Lymphoma	Bromosporine →	-1.131	-0.834	<.001	.010	3	2
BLOOD_Lymphoma	Vorinostat →	-0.525	-0.620	.002	.037	3	1
BLOOD_Lymphoma	Afatinib →	-0.339	-0.883	.005	.020	3	1
BLOOD_Lymphoma	Bortezomib →	-0.320	-0.391	.033	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Mirin by Taurine metabolic process activity — BLOOD_Lymphoma

Explore this box plot interactively →