Galactose catabolic process

Across TCGA patient cohorts, RNA activity of the Galactose catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC4, CSF2RA, and LILRA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Galactose catabolic process activity versus RFC4 in LSCC (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC4 →	-0.991	-0.160	<.001	<.001	3	5
GBM	CSF2RA →	+0.686	+0.085	.008	.004	3	5
UCEC	LILRA1 →	+0.372	+0.050	.002	.009	3	5
LSCC	BIRC5 →	-1.111	-0.154	<.001	<.001	3	5
LSCC	CDC45 →	-0.782	-0.126	<.001	<.001	3	5
BRCA	DOCK8-AS1 →	+0.280	+0.073	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019388 vs RFC4 — LSCC

Explore this scatter interactively →