Regulation of vasoconstriction

Across TCGA cell cohorts, RNA activity of the Regulation of vasoconstriction pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATB, SP140, and TXNDC17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GATB grouped by Regulation of vasoconstriction-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GATB →	+0.565	+0.591	.005	.003	3	4
KIDNEY	SP140 →	-1.375	-1.019	.005	<.001	3	4
BREAST	TXNDC17 →	-0.629	-0.652	.001	.004	3	3
CNS	TNFSF9 →	-1.538	-0.770	.002	.001	3	3
LIVER	SLFN5 →	-1.551	-0.929	.003	.002	3	3
SKIN	NR2F6 →	+0.532	+0.787	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GATB by Regulation of vasoconstriction activity — LARGE_INTESTINE

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