Phenol-containing compound metabolic process

Across TCGA cell cohorts, RNA activity of the Phenol-containing compound metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH2, SDCBP, and MGST3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound metabolic process activity versus ALDH2 in LUNG_NSCLC_LUAD (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ALDH2 →	+1.645	+0.323	.003	<.001	3	6
SKIN	SDCBP →	+1.417	+0.453	.002	<.001	3	5
STOMACH	MGST3 →	+1.774	+0.362	.007	<.001	3	5
SKIN	TANGO2 →	+1.121	+0.287	<.001	.005	3	4
BLOOD_Leukemia	VPS11 →	+0.544	+0.371	<.001	.001	3	4
BLOOD_Leukemia	SCAMP2 →	+0.578	+0.363	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018958 vs ALDH2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →