Ether metabolic process

pathway activity — cross-omics
GO:0018904Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Ether metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRYL1, ALDH1A1, and SPR, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCRYL1 →+0.501+0.052<.001.00237
GBMALDH1A1 →+0.632+0.045.001.00636
LUADSPR →+0.317+0.043<.001.00536
GBMSPTAN1 →+0.462+0.066<.001<.00135
BRCASYNPO2_S363 →+1.137+0.030<.001.00135
CCRCCTPD52L1 →+0.556+0.033.002.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration