Peptidyl-threonine modification

Across TCGA patient cohorts, RNA activity of the Peptidyl-threonine modification pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUVBL1-AS1, LINC01975, and EML1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-threonine modification activity versus RUVBL1-AS1 in CCRCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RUVBL1-AS1 →	-1.123	-0.366	.006	<.001	3	2
CCRCC	LINC01975 →	-0.420	-0.350	.004	<.001	3	2
CCRCC	EML1 →	-0.650	-0.366	.005	<.001	3	2
BRCA	TMED8 →	-0.678	-0.400	<.001	.003	3	2
BRCA	NEK9 →	-0.480	-0.286	<.001	.003	2	3
BRCA	NEDD1 →	-0.735	-0.472	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018210 vs RUVBL1-AS1 — CCRCC

Explore this scatter interactively →