Protein polyglutamylation

Across TCGA patient cohorts, RNA activity of the Protein polyglutamylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP4P1, IFITM1, and BATF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein polyglutamylation activity versus PARP4P1 in HNSC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PARP4P1 →	-0.235	-0.441	<.001	.001	3	4
UCEC	IFITM1 →	+1.272	+0.819	.001	<.001	3	4
BRCA	BATF2 →	+1.047	+0.422	<.001	.003	3	3
UCEC	ANP32AP1 →	-0.768	-0.645	.004	.001	3	3
OV	USP9Y →	-0.013	-0.711	.001	<.001	3	3
OV	TPT1P4 →	-1.340	-0.515	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0018095 vs PARP4P1 — HNSC

Explore this scatter interactively →