poly(ADP-ribose) polymerase family member 4 pseudogene 1Genealiases: ADPRTL1P · PARP4P · PARP4PY1
Q-omics provides the consensus-scored PARP4P1 profile across patient tissues and cancer cell-line models. PARP4P1 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, PARP4P1 is differentially expressed in 1, with the highest sampling consensus in LUSC. Additionally, PARP4P1 RNA expression shows 9,916 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight HNSC, LUSC, and UVM as cancer lineages where PARP4P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PARP4P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PARP4P1 survival associations across molecular data types. PARP4P1 RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PARP4P1 RNA expression–survival associations across cancer types. High PARP4P1 expression shows unfavorable associations in HNSC and UVM, but favorable associations in KIRC, SKCM, CESC and LUAD. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .005). Together, the overview and detailed table identify HNSC as the clearest survival context for PARP4P1 RNA expression.
This table summarizes PARP4P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for PARP4P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PARP4P1 shows lower tumor expression in LUSC. The LUSC box plot shows higher PARP4P1 RNA expression in normal versus tumor tissue (log2 FC = −0.209, t-test p = .047).
This table shows molecular features associated with PARP4P1 in patient tissues and cancer cell lines. In patient samples, PARP4P1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
