Protein nitrosylation

Across TCGA patient cohorts, RNA activity of the Protein nitrosylation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NANOGP7, ARL10, and USP10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein nitrosylation activity versus NANOGP7 in OV (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NANOGP7 →	+0.270	+0.587	.004	.007	3	4
LSCC	ARL10 →	-0.617	-0.512	.004	.004	3	4
GBM	USP10 →	-0.351	-0.393	<.001	.001	3	3
GBM	VSIR →	+0.635	+0.436	.007	.001	3	3
GBM	MACROH2A1 →	-0.297	-0.467	.002	<.001	3	3
LSCC	SMC4 →	-0.660	-0.673	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0017014 vs NANOGP7 — OV

Explore this scatter interactively →