Protein nitrosylation

Across TCGA pan-cancer cohorts, RNA activity of the Protein nitrosylation pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Protein nitrosylation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and ACC, show the opposite pattern, with higher activity associated with better survival.

BRCA, ESCA, and DLBC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.704	0.864	<.001	59	view →
ESCA	OS	Median	III,IV	0.830	0.382	<.001	47	view →
DLBC	DFS	Median	All	0.519	1.000	.002	45	view →
LGG	DFS	Median	All	0.315	0.483	<.001	43	view →
UCEC	OS	Quartile	All	0.547	0.794	.005	40	view →
THYM	OS	Quartile	All	0.352	0.896	.009	29	view →
ACC	DFS	Median	All	0.724	0.480	.016	28	view →
KIRC	DFS	Quartile	All	0.737	0.861	.001	27	view →
THCA	DFS	Tertile	IV	1.000	0.569	.012	26	view →
LUAD	OS	Median	All	0.845	0.779	.012	25	view →
SCLC	OS	Median	All	0.525	0.752	.004	25	view →
KIRP	DFS	Median	II,III,IV	1.000	0.496	.002	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0017014–BRCA (DFS)

Open the BRCA breakdown →