Protein nitrosylation

Across TCGA cell cohorts, RNA activity of the Protein nitrosylation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX7A2, PMP2, and AK5, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX7A2 grouped by Protein nitrosylation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COX7A2 →	+0.249	+0.527	.006	<.001	3	2
BLOOD_Leukemia	PMP2 →	+0.139	+0.556	.002	.006	3	2
BLOOD_Leukemia	AK5 →	+0.205	+0.482	.007	.008	3	2
BREAST	RFC4 →	-0.406	-0.414	.006	.007	3	2
BREAST	WASH8P →	+0.277	+0.483	.004	.001	3	2
BREAST	MKNK2 →	+0.202	+0.384	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX7A2 by Protein nitrosylation activity — BLOOD_Leukemia

Explore this box plot interactively →