Protein processing

Across TCGA cell cohorts, RNA activity of the Protein processing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF696, BOP1, and ZNF784, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein processing activity versus ZNF696 in CNS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF696 →	-0.473	-0.194	.003	.001	3	5
PANCREAS	BOP1 →	-1.069	-0.125	<.001	.006	2	6
LIVER	ZNF784 →	-0.876	-0.265	.002	<.001	3	5
BONE	WDR74 →	-0.721	-0.242	.004	.001	3	5
BONE	RPN2 →	+0.766	+0.182	.003	.005	3	5
STOMACH	GGA1 →	-0.633	-0.145	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016485 vs ZNF696 — CNS

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