Protein processing

Across TCGA pan-cancer cohorts, RNA activity of the Protein processing pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 243 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Protein processing pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRC, UVM, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.455	0.708	<.001	67	view →
UVM	DFS	Median	III,IV	0.317	0.685	.002	60	view →
LGG	DFS	Median	All	0.564	0.833	<.001	54	view →
HNSC	DFS	Tertile	III,IV	0.672	0.459	.001	45	view →
THYM	OS	Quartile	II,III,IV	0.778	1.000	<.001	32	view →
SKCM	OS	Tertile	III,IV	0.734	0.288	.005	32	view →
OV	DFS	Tertile	IV	0.271	0.585	.002	30	view →
DLBC	OS	Median	II,III,IV	0.520	1.000	.003	27	view →
CESC	OS	Median	IV	0.668	0.107	.009	22	view →
LAML	DFS	Quartile	All	0.243	0.562	.015	22	view →
ESCA	OS	Quartile	III,IV	0.736	0.324	.002	21	view →
GBM	DFS	Median	All	0.197	0.309	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0016485–KIRC (OS)

Open the KIRC breakdown →