Somatic diversification of immunoglobulins

Across TCGA patient cohorts, RNA activity of the Somatic diversification of immunoglobulins pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STIM1, TOP2A_S1377, and MSH2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic diversification of immunoglobulins activity versus STIM1 in LSCC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STIM1 →	-0.349	-0.035	<.001	<.001	3	7
LUAD	TOP2A_S1377 →	+0.894	+0.045	<.001	<.001	3	6
HNSC	MSH2 →	+0.435	+0.080	<.001	<.001	3	6
LUAD	MSH6 →	+0.504	+0.039	<.001	<.001	3	6
LUAD	SETDB1_S1066 →	+0.918	+0.048	<.001	<.001	3	6
LUAD	FAM50A →	+0.303	+0.035	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016445 vs STIM1 — LSCC

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