Iron-sulfur cluster assembly

Across TCGA patient cohorts, RNA activity of the Iron-sulfur cluster assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01048, SLC16A10, and RBMS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron-sulfur cluster assembly activity versus LINC01048 in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01048 →	-0.546	-0.182	.004	.009	3	4
PDAC	SLC16A10 →	-0.687	-0.154	.001	.006	3	4
GBM	RBMS1 →	-0.386	-0.117	.008	.002	2	5
PDAC	METTL17 →	+0.219	+0.134	<.001	<.001	3	4
OV	TM9SF4 →	+0.665	+0.180	.003	.004	3	3
OV	GLA →	-0.588	-0.259	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016226 vs LINC01048 — BRCA

Explore this scatter interactively →