Iron-sulfur cluster assembly

Across TCGA cell cohorts, RNA activity of the Iron-sulfur cluster assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR1, SPR, and NEK5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron-sulfur cluster assembly activity versus GPR1 in LARGE_INTESTINE (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR1 →	-1.080	-0.206	.008	.001	3	7
UPPER_AERODIGESTIVE_TRACT	SPR →	+1.018	+0.433	<.001	<.001	3	6
LIVER	NEK5 →	+0.222	+0.131	.005	.006	3	5
UPPER_AERODIGESTIVE_TRACT	OXA1L →	+0.711	+0.389	<.001	<.001	3	5
LARGE_INTESTINE	RXYLT1 →	+0.626	+0.264	.004	<.001	3	5
PANCREAS	SCLY →	+0.970	+0.144	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016226 vs GPR1 — LARGE_INTESTINE

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