Synaptic vesicle coating

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle coating pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM120A, WIPF1, and AP3B2_S272, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle coating activity versus FAM120A in BRCA (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM120A →	+0.158	+0.034	.007	.009	3	6
GBM	WIPF1 →	-0.276	-0.060	<.001	<.001	3	6
CCRCC	AP3B2_S272 →	-1.178	-0.062	<.001	.001	3	5
UCEC	VDAC3 →	+0.587	+0.053	<.001	<.001	3	5
PDAC	AP3M2 →	+0.316	+0.056	<.001	<.001	3	5
LUAD	IMPDH2_S160 →	-0.422	-0.037	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016183 vs FAM120A — BRCA

Explore this scatter interactively →