Synaptic vesicle coating

Across TCGA pan-cancer cohorts, RNA activity of the Synaptic vesicle coating pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUSC and LUAD, show the opposite pattern, with lower activity in tumor tissue.

COAD, BRCA, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Male	II,III,IV	+0.066	<.001	10	view →
BRCA	All	III,IV	+0.050	<.001	8	view →
HNSC	All	II,III,IV	+0.025	.001	7	view →
STAD	Male	II,III,IV	+0.071	<.001	5	view →
READ	All	All	+0.078	.002	3	view →
ESCA	All	All	+0.076	.005	3	view →
LUSC	Male	All	−0.041	<.001	3	view →
LUAD	Female	II,III,IV	−0.035	.022	3	view →
CHOL	All	All	+0.055	.014	2	view →
LIHC	All	All	+0.017	.012	2	view →
PRAD	All	All	+0.016	.017	2	view →
THCA	Male	III,IV	−0.030	.026	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0016183–COAD

Open the COAD breakdown →