Organic acid catabolic process

Across TCGA cell cohorts, RNA activity of the Organic acid catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP3, CGN, and FRAT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organic acid catabolic process activity versus TJP3 in BREAST (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TJP3 →	+2.178	+0.231	<.001	<.001	3	8
OVARY	CGN →	+2.860	+0.182	<.001	.003	3	8
LIVER	FRAT2 →	+2.232	+0.229	.001	<.001	2	8
SOFT_TISSUE	ITGA5 →	-2.196	-0.161	.009	.002	3	7
PANCREAS	FRMD6 →	-2.611	-0.349	.001	<.001	3	7
LIVER	SLC25A45 →	+1.824	+0.221	.007	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016054 vs TJP3 — BREAST

Explore this scatter interactively →