Carbohydrate catabolic process

Across TCGA patient cohorts, RNA activity of the Carbohydrate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPP1, NCEH1, and COMMD10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate catabolic process activity versus TPP1 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TPP1 →	+0.329	+0.038	<.001	<.001	3	4
GBM	NCEH1 →	+0.514	+0.047	<.001	<.001	3	4
OV	COMMD10 →	+0.276	+0.029	<.001	<.001	3	4
GBM	DPYD →	+0.572	+0.019	<.001	.006	3	4
GBM	PSTPIP2 →	+0.510	+0.032	.002	.003	3	4
CCRCC	ATP6V1C1 →	+0.148	+0.020	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016052 vs TPP1 — GBM

Explore this scatter interactively →