Carbohydrate catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Carbohydrate catabolic process pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 162 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Carbohydrate catabolic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BRCA, show the opposite pattern, with higher activity associated with better survival.

UVM, HNSC, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.306	0.658	<.001	70	view →
HNSC	OS	Tertile	III,IV	0.408	0.303	.002	67	view →
CESC	DFS	Tertile	II,III,IV	0.612	0.837	.002	38	view →
BRCA	DFS	Tertile	III,IV	0.941	0.802	.001	35	view →
LGG	DFS	Median	All	0.314	0.447	<.001	34	view →
SKCM	DFS	Quartile	II,III,IV	0.817	0.614	.007	28	view →
ESCA	OS	Median	III,IV	0.591	0.334	.013	25	view →
DLBC	DFS	Tertile	All	0.140	1.000	.005	24	view →
KIRC	OS	Median	All	0.517	0.684	.001	22	view →
MESO	DFS	Median	III,IV	0.291	0.557	.041	15	view →
READ	DFS	Median	IV	0.433	0.709	.003	15	view →
GBM	OS	Tertile	All	0.286	0.512	.029	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0016052–UVM (DFS)

Open the UVM breakdown →