Carbohydrate catabolic process

Across TCGA patient cohorts, RNA activity of the Carbohydrate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SULF1, FNDC1, and KIAA1549L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate catabolic process activity versus SULF1 in BRCA (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SULF1 →	-1.978	-0.255	<.001	.002	3	3
BRCA	FNDC1 →	-1.591	-0.258	<.001	.001	3	3
BRCA	KIAA1549L →	-0.781	-0.233	.001	.002	3	2
BRCA	COL12A1 →	-1.809	-0.257	<.001	.001	2	3
BRCA	FN1 →	-1.942	-0.220	.001	.007	2	3
BRCA	CALU →	-0.810	-0.268	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016052 vs SULF1 — BRCA

Explore this scatter interactively →