Carbohydrate catabolic process

Across TCGA cell cohorts, RNA activity of the Carbohydrate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A7, ZNF25, and SHOC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate catabolic process activity versus SLC4A7 in LUNG_NSCLC_LUAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC4A7 →	+1.337	+0.139	.001	.004	3	5
CNS	ZNF25 →	+0.642	+0.128	.001	.009	2	6
UPPER_AERODIGESTIVE_TRACT	SHOC2 →	+0.743	+0.321	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ESD →	+1.173	+0.340	.002	<.001	3	4
LUNG_NSCLC_LUAD	ATP5F1C →	+0.797	+0.188	.002	.006	3	4
UPPER_AERODIGESTIVE_TRACT	GHITM →	+1.191	+0.256	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0016052 vs SLC4A7 — LUNG_NSCLC_LUAD

Explore this scatter interactively →