Long-chain fatty acid transport

Across TCGA patient cohorts, RNA activity of the Long-chain fatty acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, ETV5, and SLC7A11, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty acid transport activity versus IRS2 in LUAD (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IRS2 →	+1.257	+0.355	<.001	<.001	3	8
COAD	ETV5 →	+0.922	+0.180	<.001	<.001	3	6
LSCC	SLC7A11 →	+1.848	+0.224	<.001	<.001	3	5
UCEC	FNDC3A →	+0.518	+0.167	.009	.004	3	5
LSCC	LHFPL2 →	+0.569	+0.267	<.001	<.001	3	5
COAD	HOXC-AS2 →	+0.306	+0.191	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015909 vs IRS2 — LUAD

Explore this scatter interactively →