Long-chain fatty acid transport

Across TCGA pan-cancer cohorts, RNA activity of the Long-chain fatty acid transport pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 67 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Long-chain fatty acid transport pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCEC and BRCA, show the opposite pattern, with higher activity associated with better survival.

UCS, LGG, and LAML are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	II,III,IV	0.128	0.746	<.001	80	view →
LGG	DFS	Median	All	0.601	0.834	<.001	54	view →
LAML	DFS	Tertile	All	0.252	0.501	.012	28	view →
SCLC	DFS	Quartile	II,III,IV	0.220	0.671	<.001	28	view →
UCEC	DFS	Tertile	IV	0.660	0.227	.009	24	view →
LUAD	DFS	Median	IV	0.327	0.761	.001	24	view →
BRCA	DFS	Median	III,IV	0.695	0.390	.003	23	view →
GBM	DFS	Quartile	All	0.132	0.318	<.001	21	view →
MESO	OS	Tertile	III,IV	0.301	0.539	.008	20	view →
STAD	OS	Quartile	All	0.372	0.728	.005	18	view →
HNSC	DFS	Tertile	IV	0.553	0.311	.005	17	view →
PRAD	DFS	Tertile	All	0.875	0.755	.028	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0015909–UCS (OS)

Open the UCS breakdown →