Carnitine transport

Across TCGA cell cohorts, RNA activity of the Carnitine transport pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORIN, ST13P4, and ACTR5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CORIN grouped by Carnitine transport-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CORIN →	-0.214	-1.185	<.001	.002	3	4
LIVER	ST13P4 →	-0.290	-1.715	.004	<.001	3	4
BREAST	ACTR5 →	-0.182	-0.647	<.001	.003	3	4
BREAST	ASB13 →	-0.098	-0.671	.009	.002	3	4
STOMACH	C3AR1 →	-0.201	-1.740	.001	<.001	3	3
BREAST	ARHGEF1 →	+0.134	+0.693	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CORIN by Carnitine transport activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →