Amine transport

Across TCGA patient cohorts, RNA activity of the Amine transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BOD1, MAP3K4, and LAMC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amine transport activity versus BOD1 in HNSC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BOD1 →	-0.868	-0.438	.002	.001	3	5
HNSC	MAP3K4 →	-0.509	-0.442	.006	.002	3	5
GBM	LAMC1 →	-0.783	-1.079	<.001	<.001	3	5
BRCA	RFC4 →	-0.407	-0.425	.002	.005	3	5
PDAC	RRM1 →	-0.375	-0.468	<.001	.001	3	5
BRCA	CKS1B →	-0.598	-0.619	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015837 vs BOD1 — HNSC

Explore this scatter interactively →