Amine transport

Across TCGA pan-cancer cohorts, RNA activity of the Amine transport pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 108 member genes.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher Amine transport pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LGG, show the opposite pattern, with higher activity associated with better survival.

STAD, UVM, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	II,III,IV	0.413	0.681	.003	79	view →
UVM	DFS	Median	All	0.773	0.431	<.001	67	view →
LGG	DFS	Median	All	0.809	0.674	<.001	52	view →
KIRP	OS	Quartile	III,IV	0.875	0.314	<.001	44	view →
ACC	OS	Median	IV	0.842	0.244	.001	30	view →
CESC	DFS	Median	III,IV	0.230	0.618	.003	28	view →
MESO	OS	Median	III,IV	0.103	0.649	<.001	27	view →
READ	DFS	Quartile	IV	0.290	0.765	.004	23	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	17	view →
LIHC	OS	Median	All	0.679	0.448	.002	17	view →
LUAD	OS	Tertile	III,IV	0.803	0.530	.024	15	view →
COAD	DFS	Quartile	All	0.719	0.822	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0015837–STAD (OS)

Open the STAD breakdown →