Peptide transport

Across TCGA cell cohorts, RNA activity of the Peptide transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDIA4, EPHB6, and HOXD13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDIA4 grouped by Peptide transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDIA4 →	+0.751	+0.864	.005	.007	3	4
LIVER	EPHB6 →	-3.601	-1.644	.001	<.001	3	4
SKIN	HOXD13 →	+1.553	+0.922	.003	.003	3	4
BONE	ARG1 →	+0.258	+1.035	<.001	.003	3	3
BONE	CNTN2 →	+0.076	+1.290	<.001	.001	3	3
BONE	FOXD3 →	+1.803	+1.014	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDIA4 by Peptide transport activity — LARGE_INTESTINE

Explore this box plot interactively →