Prostaglandin transport

Across TCGA patient cohorts, RNA activity of the Prostaglandin transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, SMC3, and TOPBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostaglandin transport activity versus PLA2G4A in COAD (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G4A →	+1.349	+0.952	.004	<.001	3	6
PDAC	SMC3 →	-0.377	-0.281	<.001	<.001	3	5
PDAC	TOPBP1 →	-0.216	-0.193	.002	.003	3	5
PDAC	CEP295 →	-0.248	-0.288	.001	.001	3	5
UCEC	RFC2 →	-0.557	-0.248	.009	.002	3	4
GBM	CDCA3 →	-0.487	-0.189	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015732 vs PLA2G4A — COAD

Explore this scatter interactively →