Prostaglandin transport

Across TCGA pan-cancer cohorts, RNA activity of the Prostaglandin transport pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and LUAD, show the opposite pattern, with lower activity in tumor tissue.

KICH, LUAD, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	Female	II,III,IV	−0.092	<.001	11	view →
LUAD	All	III,IV	−0.057	<.001	9	view →
LIHC	All	II,III,IV	−0.054	<.001	8	view →
LUSC	Female	All	−0.074	<.001	7	view →
BRCA	All	III,IV	−0.077	<.001	6	view →
KIRP	Female	All	−0.052	.004	6	view →
KIRC	Male	II,III,IV	−0.030	<.001	4	view →
UCEC	All	All	−0.040	.004	2	view →
THCA	All	All	−0.015	.011	2	view →
CHOL	All	All	−0.054	.010	1	view →
STAD	All	All	+0.031	.036	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0015732–KICH

Open the KICH breakdown →