Inorganic anion transport

Across TCGA cell cohorts, RNA activity of the Inorganic anion transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMF, SPART, and PFKFB4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMF grouped by Inorganic anion transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BMF →	-1.158	-0.732	<.001	.001	3	5
SOFT_TISSUE	SPART →	+2.861	+1.143	.005	.007	3	4
LUNG_NSCLC_LUSC	PFKFB4 →	-0.736	-1.587	.006	<.001	3	4
STOMACH	CKAP2 →	+0.633	+0.778	.001	.004	3	3
STOMACH	GTF2H2C →	+1.358	+1.204	.001	.006	3	3
BREAST	ZNF491 →	-0.596	-0.842	.006	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMF by Inorganic anion transport activity — CNS

Explore this box plot interactively →