Inorganic anion transport

Across TCGA cell cohorts, RNA activity of the Inorganic anion transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXA1, OCM, and TMEM87A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inorganic anion transport activity versus HOXA1 in KIDNEY (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HOXA1 →	-1.529	-0.186	.002	.005	3	4
OVARY	OCM →	-0.080	-0.174	.005	.006	3	4
LUNG_SCLC	TMEM87A →	-0.912	-0.253	.004	.002	2	5
BLOOD_Lymphoma	MRPL51 →	+0.757	+0.310	<.001	<.001	3	4
SOFT_TISSUE	HOXA3 →	-2.518	-0.225	<.001	.009	3	4
BONE	GPR89A →	-1.171	-0.442	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015698 vs HOXA1 — KIDNEY

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