Negative regulation of smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKH, NKIRAS1, and SGPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANKH grouped by Negative regulation of smooth muscle cell migration-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ANKH →	-0.244	-0.121	.004	.005	3	5
CNS	NKIRAS1 →	+0.167	+0.115	.005	<.001	3	5
LUNG_NSCLC_LUAD	SGPP1 →	+0.114	+0.100	.004	.009	2	6
SOFT_TISSUE	HNRNPCL1 →	+0.385	+0.191	.006	.005	3	5
BLOOD_Myeloma	HERC2 →	+0.424	+0.060	.003	.002	3	4
BLOOD_Myeloma	CFAP57 →	-0.422	-0.083	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANKH by Negative regulation of smooth muscle cell migration activity — CNS

Explore this box plot interactively →