Myotube differentiation

Across TCGA patient cohorts, RNA activity of the Myotube differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, SORBS3, and RPL5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myotube differentiation activity versus RSU1 in BRCA (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RSU1 →	+0.441	+0.030	<.001	<.001	3	7
UCEC	SORBS3 →	+0.458	+0.035	<.001	<.001	3	7
OV	RPL5 →	-0.220	-0.043	.001	<.001	3	7
UCEC	HAAO →	+0.645	+0.041	<.001	<.001	3	7
BRCA	HIC1_S704 →	+0.572	+0.020	<.001	<.001	3	7
BRCA	NID2 →	+0.448	+0.019	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014902 vs RSU1 — BRCA

Explore this scatter interactively →