Regulation of skeletal muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFLAR, PPARD, and SIX1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle cell proliferation activity versus CFLAR in BLOOD_Lymphoma (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CFLAR →	+1.359	+0.067	<.001	<.001	3	9
PANCREAS	PPARD →	+1.325	+0.131	<.001	<.001	3	8
SOFT_TISSUE	SIX1 →	+2.279	+0.105	<.001	<.001	3	7
LUNG_NSCLC_LUSC	GAB2 →	+1.272	+0.140	.003	.006	3	6
BLOOD_Lymphoma	STAT3 →	+1.960	+0.106	<.001	<.001	3	6
PANCREAS	IRF9 →	+1.134	+0.089	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014857 vs CFLAR — BLOOD_Lymphoma

Explore this scatter interactively →