Skeletal muscle cell proliferation

Across TCGA cell cohorts, RNA activity of the Skeletal muscle cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC157, POGLUT2, and PHLDA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC157 grouped by Skeletal muscle cell proliferation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CCDC157 →	-0.880	-1.511	<.001	<.001	3	5
LIVER	POGLUT2 →	+2.929	+1.858	.001	<.001	3	4
LUNG_SCLC	PHLDA1 →	+3.486	+1.614	<.001	.001	3	4
LUNG_SCLC	SOWAHC →	+1.350	+1.271	.004	<.001	3	4
OESOPHAGUS	TSPAN18 →	+2.474	+1.777	.001	<.001	3	3
OESOPHAGUS	THAP5 →	+0.715	+1.777	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC157 by Skeletal muscle cell proliferation activity — LUNG_SCLC

Explore this box plot interactively →