Skeletal muscle satellite cell proliferation

pathway activity — cross-omics
GO:0014841Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Skeletal muscle satellite cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF367, TMPO, and GAS2L3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAZNF367 →+0.596+0.391.002.00234
BRCATMPO →+0.546+0.513.006.00134
BRCAGAS2L3 →+0.431+0.452.004.00134
UCECNDUFB4P4 →-0.292-0.543<.001<.00133
UCECZNF33BP1 →-0.774-0.537<.001<.00133
LUADCD69 →+0.437+0.415.007.00933
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration