Regulation of somitogenesis

pathway activity — cross-omics
GO:0014807Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of somitogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNIH3-AS1, OR7E13P, and ADAM21, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACCNIH3-AS1 →+0.537+0.779.009.00133
HNSCOR7E13P →+0.597+0.111.002.00833
LSCCADAM21 →+0.308+0.165.004.00733
CCRCCEHD3 →+0.636+0.254.006.00932
CCRCCMETTL21A →+0.253+0.387.002<.00132
CCRCCDHRSX →+0.545+0.389.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration